
Canine spleen cancer, also known as splenic hemangiosarcoma, is a common type of cancer in dogs.
This cancer is often slow-growing and can go undetected for a long time, making it challenging to diagnose.
The spleen plays a vital role in filtering the blood and storing red blood cells, which is why cancer in this organ can be particularly serious.
Symptoms of canine spleen cancer may include lethargy, loss of appetite, and pale gums.
In some cases, the cancer can cause the spleen to rupture, leading to a life-threatening emergency.
Dogs of any age can develop canine spleen cancer, but it's most common in middle-aged to older dogs.
The exact cause of canine spleen cancer is still unknown, but it's thought to be related to genetic and environmental factors.
Readers also liked: Canine Spleen Anatomy
Causes and Types
Canine spleen cancer is a complex and multifaceted disease, and understanding its causes and types is crucial for pet owners and veterinarians alike.
Some breeds may be more prone to splenic tumors than others, including German Shepherds, Labrador Retrievers, Golden Retrievers, Boxers, and Standard Poodles.
Additional reading: Golden Retriever Hemangiosarcoma

The cause of most splenic tumors is unknown, but veterinarians often diagnose them in older dogs.
Bernese Mountain Dogs and Flat-Coated Retrievers may have a genetic link to histiocytic sarcoma, a particularly aggressive form of splenic cancer.
Splenic cancer can be caused by random mutations in the cells making up the spleen, with no known cause or way to predict or prevent its development.
Here are some common malignant tumors found in the spleen:
- Lymphoma or lymphosarcoma: This type of tumor is highly variable and typically involves the lymph nodes as well as other organs.
- Leukemia: This cancer of cells within the bone marrow can originate in or infiltrate the spleen.
- Histiocytic sarcoma: This type of sarcoma is common in Bernese Mountain Dogs and carries a poor prognosis.
- Other round cell tumors, such as mast cell tumors, plasma cell tumors, and multiple myeloma, also occur in the spleen.
Causes of Dog Spleen Cancer
Spleen cancer in dogs is often just a random mutation in the cells making up the spleen, with no known cause. This means there's nothing you can do to predict or prevent spleen cancer from developing.
Certain breeds, such as German Shepherds, Cocker Spaniels, and Labrador Retrievers, may have a higher risk of spleen cancer due to potential genetic risk factors. More research is needed to determine the exact role of genes in canine spleen cancer.
Curious to learn more? Check out: Canine Spleen Cancer Symptoms

Some breeds, like Bernese Mountain Dogs and Flat-Coated Retrievers, may have a genetic link to histiocytic sarcoma, a type of spleen cancer. This highlights the importance of knowing your dog's breed and potential genetic predispositions.
The likelihood of a splenic mass being malignant varies depending on several factors, including the size of the mass, the presence of symptoms, and the dog's breed and age. For example, small-breed dogs are more likely to have benign disease.
Here's a rough estimate of the likelihood of malignancy based on different factors:
Keep in mind that these are general estimates, and the actual likelihood of malignancy can only be determined through further testing and evaluation by a veterinarian.
What's in It for Dogs?
Spleen cancer can be especially sneaky in dogs, often going undetected until it's quite advanced.
In its early stages, spleen cancer may not cause many symptoms, making it difficult to detect.
Dogs with spleen cancer may eventually collapse due to severe internal bleeding and require emergency surgery.
The spleen is a vital organ that filters the blood and stores red blood cells, making spleen cancer a serious concern for canine health.
In some cases, vets discover splenic cancer in dogs when investigating other health concerns, like mild anemia caused by a slowly bleeding spleen tumor.
Symptoms and Diagnosis

Symptoms of canine spleen cancer can be subtle or even nonexistent, and they're often discovered during a diagnostic test for another condition. The spleen contains many blood vessels, making even benign tumors prone to rupture and bleeding.
Common signs of a spleen tumor or bleeding include lethargy, decreased appetite, weakness, collapse, pale gums, abdominal enlargement, cold limbs, and heart arrhythmia.
If spleen cancer progresses, you might notice related symptoms such as pale gums, low body temperature, reluctance to move, lethargy, or weakness, abdominal swelling, and increased heart rate and fast breathing.
To diagnose canine spleen cancer, your veterinarian will perform a physical exam, paying attention to gum color, heart rate, and feeling the abdomen. Blood tests can also detect concurrent issues or conditions caused by splenic tumors, but imaging, such as ultrasound or X-rays, is often necessary to confirm the diagnosis.
Symptoms of Canine Spleen Cancer
Symptoms of canine spleen cancer can be quite subtle, and often go unnoticed until it's too late. Lethargy is a common sign, where your dog becomes less energetic and less interested in activities they normally enjoy.

Decreased appetite and weakness are also frequent symptoms, making it difficult for your dog to get the nutrients they need to stay healthy.
Collapse is a more serious sign, where your dog becomes unable to stand or walk due to a lack of blood flow.
Pale gums are a sign that your dog is not getting enough oxygen, which can be a result of internal bleeding.
Abdominal enlargement, such as bloating or a swollen abdomen, can also be a symptom of spleen cancer.
Cold limbs can be a sign that your dog's circulation is being affected by the tumor.
Heart arrhythmia, or an irregular heartbeat, can also be a symptom of spleen cancer.
Here are some common symptoms of canine spleen cancer:
- Lethargy
- Decreased appetite
- Weakness
- Collapse
- Pale gums
- Abdominal enlargement
- Cold limbs
- Heart arrhythmia
If your dog is experiencing any of these symptoms, it's essential to act quickly and visit your veterinarian for a proper diagnosis.
Blood Chemistry and CBC
A veterinarian may recommend bloodwork as a first step to determine overall health after diagnosing a splenic tumor. Bloodwork can help identify potential issues related to the tumor.
For more insights, see: Mast Cell Tumor in Pit Bulls

A complete blood count (CBC) can detect anemia (low red blood cell count) and low platelets, which are common signs of a bleeding or ruptured tumor. This can help veterinarians understand the severity of the tumor.
A blood chemistry panel may show issues common to many conditions, such as dehydration, which can be a sign of a splenic tumor.
For more insights, see: Boston Terrier Mast Cell Tumor
Diagnosing Hemangiosarcoma
If you suspect your dog may have spleen cancer, or if you're simply worried because your dog's breed faces a greater risk, talk to your veterinarian about your concerns.
Your vet will perform a thorough exam to evaluate your dog's condition, paying particular attention to gum color, heart rate, and feeling the abdomen.
A physical exam alone may not be enough to diagnose spleen cancer, but it can help your veterinarian suspect a bleeding splenic tumor.
Blood tests are often a good idea, as they can detect the presence of concurrent issues, like kidney disease in dogs, as well as conditions that may be caused by splenic tumors, like anemia.

Imaging is usually the next step in diagnosing spleen cancer, and ultrasound is a good option for the spleen itself.
X-rays can also be used to diagnose spleen cancer, and it's a good idea to X-ray the chest and ultrasound the heart, as malignant tumors may already have spread to these areas.
If the tumor has not spread, your veterinarian will need to send a sample of it to the lab for analysis to determine if it is malignant or benign.
Here are the common diagnostic methods for spleen cancer:
- Physical exam
- Blood tests
- Imaging (ultrasound and X-rays)
- Tumor sampling (with spleen removal)
Diagnosis Methods
Veterinarians may suspect spleen cancer based on clinical signs and physical exam alone, with large tumors sometimes palpable through the abdominal walls.
A thorough physical exam is the first step in evaluating a dog's condition, paying attention to gum color, heart rate, and feeling the abdomen.
Blood tests are often used to detect concurrent issues, like kidney disease, and conditions caused by splenic tumors, like anemia.
For your interest: Types of Canine Cancer

Imaging is a crucial step in diagnosing spleen cancer, with ultrasound being a good option for the spleen itself, but X-rays used to diagnose spleen cancer in other areas.
If the tumor has not spread, a sample of it is sent to the lab for analysis to determine if it is malignant or benign.
A sample of abdominal fluid may be obtained by directing a needle into the abdominal fluid, which can be analyzed using a microscope to assess for cancerous cells.
This method may be more helpful in diagnosing lymphoma and mast cell tumors, but isn't accurate in all cases.
Treatment Options
Splenectomy in dogs isn't the only option for treating spleen cancer. If the tumor isn't actively bleeding, you may decide to leave it alone, but be aware that it will start bleeding eventually, making surgery more risky.
Chemotherapy may help improve life expectancy in dogs with spleen cancer, but it can be costly and may not be suitable for all dogs, depending on their age and health concerns. This treatment can cost thousands of dollars, and pet owners should be prepared for the financial burden.
Veterinary oncologists typically recommend chemotherapy after removal of splenic tumors, based on the specific tumor type. In some cases, depending on the type of tumor, chemotherapy is not necessary.
Take a look at this: Lifespan of Dog with Mast Cell Tumor
Surgery

Surgery is often the recommended treatment for primary splenic tumors, regardless of whether they're malignant or benign.
The surgery, called a splenectomy, is relatively simple and can be performed by many general practitioners, not just veterinary specialists.
The spleen is not a vital organ, so vets remove the entire spleen, not just the tumor.
Before surgery, a complete work-up is done to look at overall health and cancer spread, called cancer staging.
This may include bloodwork, x-rays of the chest, and an ultrasound of the abdomen to determine if a patient is a good surgical candidate for splenectomy.
In cases of advanced disease or poor surgical candidacy, surgery may not be recommended.
However, there are cases of malignant tumors that may still benefit from a splenectomy.
Broaden your view: Types of Dog Tumors with Pictures
Treatment Options
Splenectomy, or the removal of the spleen, is a treatment option for canine spleen cancer.
Surgery isn't always the best choice, especially if the tumor isn't actively bleeding, as this can make surgery more risky.

Chemotherapy may be an option to improve life expectancy in dogs with malignant spleen tumors.
However, chemotherapy can be costly and may not be suitable for all dogs, depending on their age and health concerns.
In some cases, pet parents may decide not to treat their dog's spleen cancer and instead opt for euthanasia when signs of internal bleeding appear.
The cost of treating spleen cancer in dogs can be significant, ranging from $800 to $1,500 for surgery alone.
Additional costs may include blood transfusions, extended hospitalization, and chemotherapy, which can increase the overall cost to $4,000 or $5,000.
Your veterinarian can provide a more accurate estimate of costs based on your dog's specific needs and location.
Medications
Medications can be used to improve a dog's quality of life if surgery is not an option.
Some medications, like Yunnan Baiyao, a Chinese herbal supplement, can help control bleeding in dogs with splenic tumors who don't have their spleen removed.
Unfortunately, steroids are prescribed in some types of cancer, but they don't cure anything and only provide a temporary improvement in quality of life.
A different take: Canine Mouth Cancer Life Expectancy
Canine Treatment Options

Splenectomy, the surgical removal of the spleen, is often recommended as treatment for primary splenic tumors.
Even benign tumors can rupture and cause life-threatening illness, making splenectomy a crucial option.
The surgery is relatively simple and can be performed by many general practitioners.
The spleen is not a vital organ, so vets remove the entire spleen, not just the tumor.
Before surgery, a complete work-up should be performed to look at overall health and cancer spread, called cancer staging.
This may include bloodwork, x-rays of the chest, and an ultrasound of the abdomen.
If the tumor isn't actively bleeding, you may decide to leave it alone, but be aware that it will start bleeding at some point, making surgery more risky.
Chemotherapy may help improve life expectancy in dogs with spleen cancer, but it can be costly and may not be suitable for all dogs.
In some cases, pet parents may decide not to treat their dog's spleen cancer and euthanize them when they show signs of internal bleeding.
Expand your knowledge: Canine Bone Cancer Life Expectancy
Prognosis and Recovery

For dogs with spleen cancer, the prognosis varies greatly depending on the type and stage of the disease. If caught early, benign tumors may only require a splenectomy to prevent rupture and hemorrhage, with a good prognosis and full life expectancy.
Dogs with malignant tumors, however, face a more guarded to grave prognosis. Many are not stable enough to undergo anesthesia due to changes in blood and coagulation factors, and may not survive surgery.
Survival times after a splenectomy range from less than a month to up to three months for dogs with splenic hemangiosarcoma, one of the most severe malignant tumors.
Additional reading: Canine Cancer Prognosis
Prognosis
The prognosis for dogs with spleen cancer varies greatly depending on the type and severity of the tumor. For dogs with benign tumors, the prognosis is generally good if caught early, with a normal life expectancy after surgery.
If the tumor is malignant, the prognosis is less promising, with most dogs surviving only a couple of months post-surgery. However, some dogs may live longer with treatment, such as chemotherapy.

Dogs with malignant tumors often have complicating factors that make surgery a high-risk procedure, and many do not survive the surgery. In fact, one study found that dogs with malignant tumors had a survival time of less than 60 days after surgery.
Early detection is crucial for a good prognosis, and surgery can be curative for benign tumors. However, the decision to operate should be based on individual circumstances, and it's essential to consider the dog's quality of life and overall health.
Here's a summary of the prognosis for dogs with spleen cancer:
It's essential to consult with a veterinarian to determine the best course of action for your dog's specific situation.
Recovery and Management
Dogs with their spleen removed require normal postoperative care including incisional monitoring and routine pain management.
They will likely have an incision from the sternum down to the pelvis.
Decreased activity is necessary for at least 10-14 days to allow for proper healing.

Biopsies are essential for a definitive diagnosis of splenic tumors.
Surgery may be curative for benign tumors with no other illnesses or complications.
Rechecks with surgeons and oncologists are scheduled initially at 2 weeks, and then every 1-3 months depending on the plan going forward.
Veterinarians will check bloodwork parameters, x-rays, and ultrasounds at these visits to monitor disease progression and quality of life.
Frequently Asked Questions
When should I euthanize my dog with spleen cancer?
When to euthanize a dog with spleen cancer depends on the severity of symptoms, with slow or non-existent bleeding and post-surgery decline being key factors to consider
What is the 2/3 rule for splenic masses in dogs?
The 2/3 rule states that approximately 2/3 of splenic masses in dogs are malignant, with hemangiosarcoma being the most common type. Two-thirds of malignant splenic masses are hemangiosarcoma, while one-third are benign.
How long can a dog live with cancer in the spleen?
Untreated splenic tumors typically last weeks to months, while treated dogs can live several months to over a year with proper care
Is spleen cancer painful for dogs?
Spleen cancer in dogs is often asymptomatic, but it can cause discomfort and pain as the tumor grows and presses on surrounding tissues. If you suspect your dog has spleen cancer, it's essential to consult a veterinarian for proper diagnosis and treatment.
Featured Images: pexels.com