
Spaying can have unintended consequences on a female dog's hormone levels. Some dogs may experience a significant drop in estrogen and progesterone, leading to behavioral and physical changes.
Hormone imbalances after spaying can cause a range of symptoms, including mood swings, anxiety, and changes in appetite and sleep patterns. In some cases, this can also lead to weight gain or loss.
A study found that up to 20% of spayed dogs experience these symptoms, which can be distressing for both dogs and their owners.
Spay Effects and Health Problems
Spaying before 2.5 years of age has a sparing effect in terms of the development of mammary tumors, and the earlier the time of spay, the greater this effect.
Early spaying can significantly reduce the risk of mammary cancer, with dogs spayed before their first heat cycle having only 0.5% of the mammary cancer risk compared to intact females.
Dogs spayed between their first and second heat cycles had an 8% risk compared to intact females, and those spayed after 2 or more heat cycles had a 26% risk compared to their intact counterparts.
Spaying after 2.5 years of age results in a risk of mammary tumors identical to the intact female population.
Common Issues After Spaying

Urinary incontinence is a common issue in spayed female dogs, particularly in middle-aged and older dogs. The volume of urine leakage varies from dog to dog.
Many veterinarians believe there's a strong correlation between spaying and urinary incontinence, based on their experience treating spayed incontinent dogs. In fact, a survey of seven research studies concluded that neutering, especially before three months, increases the risk of urinary incontinence.
Fortunately, most dogs respond to treatment consisting of oral medication and/or injections around the urethra, but some dogs with refractory urinary incontinence may end up wearing doggie diapers or being banned from the house.
Common Issues After Spaying
Spaying can have some unexpected consequences, and it's essential to be aware of them. One of the most significant issues is the potential for high luteinizing hormone levels, which can be a major contributor to health problems in spayed dogs.
Dr. Michelle Kutzler, a veterinarian at Oregon State University, has been studying the effects of spaying on hormone levels and has found that high luteinizing hormone levels can be a significant issue.
Hypothyroidism, a hormonal imbalance caused by decreased production of thyroid hormone, is another common issue that can arise after spaying. In fact, a study found that neutering is associated with a higher incidence of this disease, particularly in females.
Dogs with hypothyroidism often become sluggish, experience weight gain, and may exhibit hair loss, skin abnormalities, and heat-seeking behavior.
Urinary Incontinence in Dogs

Urinary incontinence in dogs is a common issue, particularly in middle-aged and older female dogs. It's a frustrating problem for both dogs and their owners, and it's essential to understand the potential causes.
Involuntary urine leakage can vary from dog to dog, and most dogs respond well to treatment with oral medication and/or injections around the urethra. With proper treatment, many dogs can manage their incontinence and live comfortable lives.
A 2012 survey evaluated seven previous research studies on the impact of neutering and age at the time of neutering on the risk of urinary incontinence in female dogs. The survey found weak evidence that neutering, particularly before the age of three months, increases the risk of urinary incontinence.
Many veterinarians have observed a strong correlation between spaying and urinary incontinence, based on their experience treating spayed incontinent dogs.
Countering Spay Effects
Dr. Michelle Kutzler, a veterinarian specializing in reproduction, has been studying the implications of hormone loss in dogs. She's a proponent of sterilization methods that don't disrupt natural hormones.

High luteinizing hormone (LH) levels are a possible culprit behind negative health effects of prepubertal spay and neuter. LH is a hormone that stimulates the sex organs to produce steroid hormones.
In a mature intact dog, the brain structure called the hypothalamus stimulates the pituitary gland to release LH, which then stimulates the sex organs to produce hormones. This creates a negative feedback loop that regulates LH levels.
After spay and neuter, the sex organs are removed, and there's no longer a message to the brain to stop releasing LH. This can lead to high LH levels in spayed and neutered dogs.
Dr. Kutzler has found LH receptors throughout the body, suggesting that high LH levels may be the mechanism connecting a lack of natural hormones from gonadectomy to negative health outcomes.
How Can I Assist?
Providing naturally occurring lignans in a nutrient-rich diet is key to supporting your dog's physical and emotional health after spaying. This can be achieved with a quality, species-appropriate food source and effective nutritional supplements.

Exercise is also crucial in keeping your dog's bones, joints, and muscles healthy, which can be compromised by hormone imbalance. Regular physical activity can help combat the process of diminishment.
A nutrient-rich diet can help your dog absorb nutrients from their chosen food, whether kibble, wet, or raw. Our pet nutritional products can provide the necessary support that commercial pet food often lacks.
Frequently Asked Questions
How long does it take for hormones to balance after spaying a dog?
Hormone balance after spaying typically takes 2-3 weeks, with some dogs taking up to 3 weeks to fully adjust. Monitor your dog's behavior closely during this time for optimal recovery.
Do female dogs have mood swings after being spayed?
After being spayed, female dogs typically experience more consistent behavior and are less prone to mood swings. However, females may still exhibit aggressive behaviors due to hormonal fluctuations
Sources
- https://healthyandhappydog.com/countering-the-effects-of-spay/
- https://www.akcchf.org/educational-resources/library/articles/exploring-how-spayneuter.html
- https://www.parsemus.org/2022/12/is-high-luteinizing-hormone-after-spay-or-neuter-the-cause-of-health-problems/
- https://biologicvet.ca/hormonal-impact-of-getting-your-pet-fixed/
- https://www.spayneuteradvice.com/whats-at-risk
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