As a dog owner, seeing your furry friend suffer from hemangiosarcoma can be devastating. Hemangiosarcoma is a type of cancer that affects the blood vessels, and it's one of the most common cancers in dogs.
It's essential to provide your dog with a comfortable and supportive environment during their last days. This can be as simple as creating a quiet and cozy space for them to rest.
Caring for your dog during their last days requires a lot of time and effort, but it's worth it to make their final moments as comfortable as possible. You can also consider seeking professional help from a veterinarian or a pet hospice service.
Keep your dog's favorite toys and blankets nearby to provide a sense of familiarity and comfort.
A unique perspective: Giving Birth Days
Treatment
Treatment options for hemangiosarcoma vary depending on the location of the tumor. For dermal hemangiosarcoma, surgical removal can be curative, with a reported median survival time of 780 days.
Surgery is not always possible for subcutaneous hemangiosarcoma, and in these cases, chemotherapy and/or radiation therapy may be recommended. The median survival time for subcutaneous hemangiosarcoma is 172-307 days.
Visceral hemangiosarcoma requires aggressive therapies, often including emergency surgery to remove bleeding masses in internal organs. The spleen can be surgically removed, but surgery alone does not appear to confer a marked survival benefit, with reported median survival times of 19-86 days.
Chemotherapy after surgery is often recommended, especially since hemangiosarcoma is highly malignant and readily metastasizes. The use of doxorubicin is associated with longer survival times, with reported median survival times of 141-179 days for splenic hemangiosarcoma treated with surgery and doxorubicin-based chemotherapy.
Some new treatments have shown promise in recent studies, including antibody therapy that inhibits the activity of vascular endothelial growth factor (VEGF), which stimulates angiogenesis. Immunotherapy with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) has also been used in combination with splenectomy and systemic chemotherapy.
Other promising new treatments include I'm-Yunity, a compound derived from the mushroom Coriolus versicolor, which has shown significant improvement in survival times in dogs with splenic hemangiosarcoma. The median survival time for dogs treated with I'm-Yunity was 199 days compared to 86 days for those who only underwent surgery.
A new drug called eBAT has also shown exciting results, with a 6-month survival rate of approximately 70% and 21% of dogs living more than 450 days.
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Canine Hemangiosarcoma
As a pet owner, it's heartbreaking to see your furry friend suffer from hemangiosarcoma. Weight loss and wasting are common symptoms in dogs with this condition.
These symptoms can be subtle at first, but they can quickly progress to more severe issues like weakness, lameness, and collapse.
Dogs with hemangiosarcoma may also experience seizures, dementia, and confusion. Pale mucous membranes can be a sign of internal bleeding due to the tumor.
Here are some common symptoms of canine hemangiosarcoma:
- Weight loss
- Wasting
- Weakness
- Lameness
- Collapse
- Muscle incoordination
- Partial loss of muscle control
- Seizures
- Dementia, confusion
- Pale mucous membranes due to internal bleeding
- Acute blood loss
- Palpable or visible abdominal mass
- Rapid heartbeat
- Abdominal swelling due to fluid buildup
- Excessive bruising
Canine Splenic
Canine Splenic Hemangiosarcoma is a serious condition that affects the spleen, one of the vital organs in a dog's body. It's a type of cancer that can cause a range of symptoms, including weight loss and wasting.
Symptoms of splenic hemangiosarcoma can be quite varied, and may include lameness, collapse, and seizures. In some cases, dogs may experience pale mucous membranes due to internal bleeding, or rapid heartbeat.
One of the most common symptoms of splenic hemangiosarcoma is a palpable or visible abdominal mass, which can be felt by a veterinarian during a physical examination. This mass can also cause abdominal swelling due to fluid buildup.
Diagnosing splenic hemangiosarcoma requires a combination of physical examination, medical history, and laboratory tests. Your veterinarian will need to conduct a thorough examination, including a chemical blood profile, complete blood count, and urinalysis, to assess your dog's kidney and liver function.
Here are some key laboratory tests that may be used to diagnose splenic hemangiosarcoma:
- Chemical blood profile to measure urea, nitrogen, and creatinine levels
- Complete blood count to check red and white blood cell and platelet levels
- Urinalysis to assess kidney health and detect high levels of protein and bilirubin
If these tests confirm compromised liver and kidney functioning, your veterinarian may use imaging tests such as X-rays, ultrasound, or echocardiography to obtain a diagnosis. A fine needle aspiration biopsy may also be performed to confirm the diagnosis.
Can Some Dogs Be More Susceptible?
Some breeds are considered to be at higher risk of developing hemangiosarcoma, including Golden Retrievers, Portuguese Water Dogs, Boxers, and German Shepherd Dogs.
These breeds may be more prone to genetic mutations that contribute to the development of HSA.
Dogs of any breed, including mixed breeds, and of either sex, can develop hemangiosarcoma.
HSA is more common in senior dogs aged between 8 and 12 years, but it can occur in dogs as young as 2 and as old as 15.
The exact reason why dogs are susceptible to HSA is still unknown.
Early Detection and Research
Early detection is a crucial aspect of managing hemangiosarcoma, and researchers are working tirelessly to develop new diagnostic tests. Cornell's Coonrod Lab received a grant to develop ways to identify HSA and differentiate it from non-life-threatening conditions, which could lead to earlier detection and more informed treatment decisions.
Screening at-risk breeds at annual wellness checkups could detect HSA in the early stages, allowing for surgery on the spleen while the dog is stable. This is a promising development, as it could greatly improve treatment outcomes.
Researchers at Tufts Cummings School of Veterinary Medicine are also working on a blood test for early detection and identifying genetic changes that may drive resistance to therapy. A clinical trial at the University of Pennsylvania School of Veterinary Medicine is examining the safety and efficacy of a chemotherapy drug called Copanlisib, which has shown promise in slowing the growth and spread of human cancers.
Take a look at this: Canine Hemangiosarcoma Treatment
New Treatments
New treatments for hemangiosarcoma are being explored, offering hope for dogs with this aggressive cancer. Researchers at the University of Pennsylvania's School of Veterinary Medicine are investigating antibody therapy to inhibit vascular endothelial growth factor, or VEGF, which stimulates angiogenesis.
This protein is involved in the formation of new blood vessels, a process implicated in hemangiosarcoma. Another promising treatment is immunotherapy with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE), which has shown a significant survival benefit in dogs with splenic hemangiosarcoma.
However, this therapy is not commercially available in the US. A newer compound called I'm-Yunity, derived from the mushroom Coriolus versicolor, has also shown promise in improving survival times in dogs with splenic hemangiosarcoma.
Here are some of the new treatments being explored:
- Antibody therapy to inhibit VEGF
- Immunotherapy with liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE)
- I'm-Yunity, a compound derived from the mushroom Coriolus versicolor
- eBAT, a new drug that improved the 6-month survival rate to approximately 70%
Early Detection Research
Researchers are working hard to develop new diagnostic tests for canine hemangiosarcoma. One of the most promising areas of research is the development of a blood test for early detection.
The Tufts Cummings School of Veterinary Medicine is leading this effort, and their goal is to identify which genetic changes may drive resistance to therapy. This could be a game-changer for dog owners who want to make informed decisions about their pet's treatment.
Several institutions are also working on clinical trials to test new treatments for hemangiosarcoma. For example, the University of Pennsylvania School of Veterinary Medicine is conducting a trial to examine the safety and efficacy of a chemotherapy drug called Copanlisib.
Here are some of the institutions involved in early detection research:
- Cornell’s Coonrod Lab
- Tufts Cummings School of Veterinary Medicine
- University of Pennsylvania School of Veterinary Medicine
- University of Minnesota College of Veterinary Medicine (The Shine On Project)
- Morris Animal Foundation
These institutions are working together to find new ways to detect hemangiosarcoma at an early stage, when it's more treatable.
Symptoms and Diagnosis
As your dog's condition worsens, it's essential to be aware of the symptoms of hemangiosarcoma and how it's diagnosed.
Weight loss and wasting are common symptoms of hemangiosarcoma in dogs, making it crucial to monitor your dog's weight and overall health.
The symptoms can be quite varied, including weakness, lameness, collapse, muscle incoordination, partial loss of muscle control, seizures, dementia, and confusion.
Pale mucous membranes due to internal bleeding and acute blood loss are also possible, making it essential to keep an eye on your dog's overall health.
A palpable or visible abdominal mass, rapid heartbeat, abdominal swelling due to fluid buildup, and excessive bruising are also symptoms that may indicate hemangiosarcoma.
Here's a list of common symptoms of hemangiosarcoma in dogs:
- Weight loss
- Wasting
- Weakness
- Lameness
- Collapse
- Muscle incoordination
- Partial loss of muscle control
- Seizures
- Dementia, confusion
- Pale mucous membranes due to internal bleeding
- Acute blood loss
- Palpable or visible abdominal mass
- Rapid heartbeat
- Abdominal swelling due to fluid buildup
- Excessive bruising
To aid in diagnosis, your veterinarian will need a thorough reporting of the onset of symptoms, including as much detail about the symptoms and their severity as possible.
A chemical blood profile, complete blood count, and urinalysis will be conducted to assess kidney and liver functioning, as well as to determine if your dog has anemia or a low platelet count.
Imaging tests such as X-rays, ultrasound, and echocardiography may be used to view a possible mass in the abdomen, assess the spleen and liver, and detect compromised heart functioning due to a cancerous mass.
A fine needle aspiration biopsy may be performed to confirm a diagnosis and sent to the lab for analysis.
Recovery and Advice
As your dog navigates the last days with hemangiosarcoma, it's essential to prioritize their comfort and safety. Your dog will be sore after surgery, so it's crucial to restrict activity to avoid sudden hemorrhage.
Provide your dog with a quiet, comfortable place away from stimuli to promote rest. This will help them recover more effectively. Your veterinarian may prescribe pain medication as part of the palliative treatment program, so be sure to follow directions and administer as prescribed.
Spleen and Liver Recovery in Dogs
Spleen and Liver Recovery in Dogs requires close monitoring at home and frequent follow-up visits.
Your dog will be sore after surgery, so it's essential to provide a quiet, comfortable place away from stimuli to promote rest.
Restricting activity is necessary to avoid sudden hemorrhage, so be sure to keep your dog calm and relaxed.
Pain medication may be prescribed as part of the palliative treatment program, so follow your veterinarian's directions and administer as prescribed.
Your dog's comfort and safety are top priorities during recovery, so be prepared to make some adjustments to their daily routine.
Spleen and Liver Advice from Veterinary Professionals
If your dog is diagnosed with spleen and liver hemangiosarcoma, it's essential to be aware of the potential symptoms and how they can affect your pet's quality of life.
Weight loss and wasting are common symptoms of this condition, often accompanied by weakness and lameness.
The severity of symptoms can vary, but in severe cases, dogs may experience collapse, muscle incoordination, and partial loss of muscle control.
Your veterinarian will likely conduct a chemical blood profile to assess kidney and liver function, which may reveal high levels of urea, nitrogen, and creatinine, as well as low albumin and bilirubin levels.
A complete blood count will also be conducted to determine if your dog has anemia or a low platelet count, both of which are signs of the disorder.
Here are some common symptoms and test results associated with spleen and liver hemangiosarcoma:
Your veterinarian may also use imaging tests such as X-rays, ultrasound, or echocardiography to assess the extent of the cancer and its impact on your dog's internal organs.
Fine needle aspiration biopsy may be used to confirm the diagnosis and determine the best course of treatment for your dog.
Frequently Asked Questions
How do I know if my dog with cancer is suffering?
Look for signs of pain in your dog, such as limping, loss of appetite, or increased vocalization, which can indicate suffering. If you notice any of these symptoms, consult with your veterinarian to determine the best course of action
Are dogs with hemangiosarcoma in pain?
Dogs with hemangiosarcoma typically don't show significant pain until the tumor ruptures, but may exhibit intermittent lethargy or fatigue beforehand
Sources
- DrSueCancerVet (drsuecancervet.com)
- published exciting results (umn.edu)
- recent study (hindawi.com)
- American College of Veterinary Internal Medicine (acvim.org)
- American College of Veterinary Emergency and Critical Care (acvecc.org)
- Canine Splenic Hemangiosarcoma (metro-vet.com)
- Canine Hemangiosarcoma - The Road from Despair to Hope (akcchf.org)
- AKC Rx (akcpetrx.com)
- Hemangiosarcoma is known as a “silent killer” (aaha.org)
- Dr. Jaime Modiano (modianolab.org)
- most significantly mutated gene to be tumor suppressor TP53 (nih.gov)
- clinical trial (upenn.edu)
- Tufts Cummings School of Veterinary Medicine (tufts.edu)
- Liver and Spleen Cancer (Hemangiosarcoma) in Dogs (wagwalking.com)
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