Understanding the Hereditary Factors of Hemangiosarcoma in Dogs

Hemangiosarcoma in dogs is a complex and multifaceted disease, and understanding its hereditary factors is crucial for pet owners and breeders alike.

Research suggests that some breeds, such as German Shepherds and Golden Retrievers, are more prone to hemangiosarcoma due to their genetic makeup.

Genetic mutations, like the MYB-FUS fusion gene, have been identified in some cases of hemangiosarcoma in dogs, indicating a possible hereditary link.

Studies have shown that dogs with a family history of hemangiosarcoma are more likely to develop the disease themselves.

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Hemangiosarcoma is a highly invasive canine cancer that causes blood vessels to branch, fragment, become leaky, and ultimately rupture.

It's the cause of about two-thirds of heart and splenic tumors, with metastasis affecting the liver, lungs, lymph nodes, and bones. A less common form of hemangiosarcoma affects the skin.

This cancer is known as a "silent killer" because dogs often show no symptoms until the tumor has grown so large that it ruptures and spreads—too late to save the dog's life.

Hemangiosarcoma is responsible for approximately 300,000 dog deaths in the U.S. annually, representing between 5% and 7% of the approximately 6 million canine cancers newly diagnosed each year.

Dogs with hemangiosarcoma may experience episodes of weakness that are often so brief they're easy to miss.

Symptoms of hemangiosarcoma can be subtle, making it hard to detect the disease before it's too late.

Hemangiosarcoma in dogs may have a genetic component, as it is more commonly diagnosed in certain breeds. Gene studies have identified mutations, with the tumor suppressor TP53 gene being one of the most significantly mutated.

Breeds like Golden Retrievers, Portuguese Water Dogs, Boxers, and German Shepherd Dogs are considered to be at higher risk of developing hemangiosarcoma. Dr. Jaime Modiano notes that any dog, regardless of breed or sex, can develop this cancer.

While the exact reason for this susceptibility is unknown, it's believed to be linked to the breed's genetic makeup.

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Hemangiosarcoma in dogs is a highly invasive canine cancer that causes blood vessels to branch, fragment, become leaky, and ultimately rupture.

This cancer is responsible for about two-thirds of heart and splenic tumors, and metastasis can affect the liver, lungs, lymph nodes, and bones.

Hemangiosarcoma is often referred to as a "silent killer" because dogs often show no symptoms until the tumor has grown so large that it ruptures and spreads.

Approximately 300,000 dog deaths in the U.S. annually are attributed to hemangiosarcoma, which represents between 5% and 7% of the approximately 6 million canine cancers newly diagnosed each year.

Dogs with hemangiosarcoma may experience episodes of weakness, which can be so brief that they're easy to miss.

The clinical signs of hemangiosarcoma are recurrent, but they can also be subtle enough to go unnoticed for some time.

Internal bleeding from a ruptured tumor can result in sudden death, and dogs may arrive at an emergency clinic having suddenly collapsed with pale gums.

Symptoms of hemangiosarcoma include loss of appetite, ataxia, fatigue, weakness, and pale gums.

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Dogs of certain breeds are more susceptible to hemangiosarcoma, including Golden Retrievers, Portuguese Water Dogs, Boxers, and German Shepherd Dogs.

Hemangiosarcoma is a highly invasive canine cancer that affects the blood vessels, causing them to branch, fragment, and rupture, often resulting in internal bleeding.

While any dog can develop hemangiosarcoma, regardless of breed or sex, senior dogs between 8 and 12 years old are more commonly diagnosed.

Dogs as young as 2 and as old as 15 have been diagnosed with hemangiosarcoma, but the exact reason for this susceptibility is unknown.

Male dogs are slightly more predisposed to hemangiosarcoma than their female counterparts.

Hemangiosarcoma is rarely seen in livestock, such as horses, cows, and goats, which suggests that there may be a genetic component to the disease in dogs.

Hemangiosarcoma in dogs is likely influenced by heritable factors, as it exclusively occurs in this species. The interactions of these risk factors with the environment probably lead to the mutations that give rise to the tumor.

Lesions arise when cells gather mutations that render the normal constraints of growth and genetic integrity of cells null and void. Mutations can occur in the body regularly due to the constant division of some cells to replace dead or damaged cells.

Exposure to sunlight is thought to contribute to the development of cutaneous hemangiosarcoma, a type of hemangiosarcoma found on the skin.

Hemangiosarcoma is often called "the silent killer" because it can show no signs until it's already become untreatable. Veterinarians can't easily tell if a mass on the spleen is potentially deadly or benign.

The only way to determine if a mass is hemangiosarcoma is to send a sample away to a pathologist for testing. This can be a difficult and expensive process for dog owners who are already facing a life-or-death situation.

Dr. Scott Coonrod is leading an investigation into the basic biology of hemangiosarcoma using next-generation sequencing technology. This could lead to diagnostic tests for screening at-risk dogs and rapidly identifying cancer in the clinic.

Diagnosing hemangiosarcoma in dogs requires a thorough physical exam to identify any masses. If a mass is found, imaging tests like ultrasound or radiographs (x-rays) are used to confirm its presence.

A biopsy is necessary to definitively diagnose hemangiosarcoma, where a sample of the affected tissue or the entire mass is removed and examined by a pathologist. Careful analysis of blood samples by an experienced pathologist may hint at the presence of bleeding episodes and blood vessel abnormalities.

Basic blood and urine tests, chest x-rays, and ultrasound examination of the abdomen and potentially the heart are used to determine if the tumor has spread to other areas. These tests are relatively sensitive, but artifacts can obscure the interpretation of any of these tests.

Ultrasound of the heart can identify the presence of a tumor in the heart 65-90% of the time. Advanced imaging modalities like computed tomography (CT) and positron emission tomography scans (PET-CT) are being used more commonly and appear to be more sensitive than conventional x-rays and ultrasound.

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Hemangiosarcoma, also known as the "silent killer", often shows no signs until it's too late.

This cancer is a highly invasive canine cancer that causes blood vessels to branch, fragment, become leaky, and ultimately rupture.

It's the cause of about two-thirds of heart and splenic tumors, with metastasis affecting the liver, lungs, lymph nodes, and bones.

A less common form of hemangiosarcoma affects the skin.

Dogs often show no symptoms until the tumor has grown so large that it ruptures and spreads, making it too late to save their life.

Hemangiosarcoma is responsible for approximately 300,000 dog deaths in the U.S. annually, representing between 5% and 7% of the approximately 6 million canine cancers newly diagnosed each year.

Symptoms of hemangiosarcoma can be subtle, including loss of appetite, ataxia, fatigue, weakness, and pale gums.

Internal bleeding sometimes results in sudden death, making it a silent killer.

Veterinarians often can't easily tell whether a mass on the spleen is potentially deadly, and currently the only course of action is sending a sample away to a pathologist for testing.

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This can lead to a terrible choice: euthanize the dog or pay for an expensive surgery in the hope that the growth is not hemangiosarcoma.

Dr. Scott Coonrod is leading an investigation into the basic biology of the tumor using next-generation sequencing technology to find differences among hemangiosarcoma, benign tumors, and healthy spleen tissue.

This study aims to lead to diagnostic tests for screening at-risk dogs and rapidly identifying cancer in the clinic.

Standard treatment for the splenic form involves removing the spleen and chemotherapy, but treatment usually only prolongs the dog's life by a few months.

Hemangiosarcoma is universally fatal, and we don't have good treatments and we don't understand the pathogenesis.

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