How Fast Does Lymphoma Spread in Dogs and Their Lifespan

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Posted Oct 26, 2024

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Wooden Sign with the Letters Hodgkin Lymphoma
Credit: pexels.com, Wooden Sign with the Letters Hodgkin Lymphoma

Lymphoma in dogs can progress rapidly, with some types spreading as quickly as a few weeks.

The median survival time for dogs with lymphoma is around 300 days, although this can vary depending on the type of lymphoma and the dog's overall health.

In some cases, lymphoma can progress to a more advanced stage in just a few months, making prompt treatment crucial.

Prompt treatment can significantly improve a dog's quality of life and lifespan, so it's essential to work closely with a veterinarian to develop a treatment plan.

Understanding Lymphoma in Dogs

Lymphoma is a type of cancer that affects a dog's immune system, specifically the lymphatic system.

The lymphatic system is a network of vessels, organs, and tissues that help fight infection and disease.

Lymphoma can start in the lymph nodes, spleen, or other parts of the lymphatic system, and can spread to other areas of the body.

The most common types of lymphoma in dogs are B-cell lymphoma, T-cell lymphoma, and cutaneous lymphoma.

Credit: youtube.com, Does your dog have cancer? Lymphoma in the Dog. Vet explains symptoms, diagnosis, and treatment.

B-cell lymphoma is the most common type, accounting for about 80% of all lymphoma cases in dogs.

Dogs with B-cell lymphoma often experience symptoms such as weight loss, lethargy, and swollen lymph nodes.

Lymphoma can be classified as either indolent or aggressive, with indolent lymphoma progressing slowly and aggressive lymphoma spreading quickly.

Aggressive lymphoma is more common in dogs, accounting for about 70% of all lymphoma cases.

The prognosis for dogs with lymphoma varies depending on the type and stage of the disease.

Early detection and treatment can improve a dog's chances of survival and quality of life.

Symptoms and Diagnosis

Symptoms of lymphoma in dogs can be subtle at first, but as the disease progresses, they can become more noticeable. Swollen lymph nodes, decreased appetite, and lethargy are common symptoms, but it's essential to have any swollen lymph nodes checked out by a veterinarian.

Lymphoma that appears on the skin can be mistaken for an infection or allergy, but it starts with red, flaky, itchy patches that eventually become red, moist, open sores. These sores can be painful and may not heal properly.

Credit: youtube.com, Understanding Your Pet's Diagnosis: Lymphoma

A veterinarian will typically diagnose canine lymphoma with a biopsy, or the extraction of a sample cancer cell for microscopic analysis. Bloodwork and additional lab tests, such as a urinalysis, may also be ordered to check if the organs are functioning properly.

The staging of lymphoma is complex, but it generally follows a five-stage outline:

Stages III-V are more common, and veterinarians rarely catch and diagnose dogs in stages I and II.

Canine Cancers

Cancerous lymphocytes can invade organs such as the spleen, liver, kidneys, and lungs, but this is usually not as obvious as lymph node swelling.

Lymphoma most commonly affects a dog's lymph nodes, causing them to increase dramatically in size, often in a matter of days to weeks.

Dogs with lymphoma may develop swelling under their chin, on their lower neck, in their armpits, or behind their thighs, due to swollen lymph nodes that are firm and sometimes sensitive to the touch.

Credit: youtube.com, The Top 7 Symptoms of Cancer in Dogs

The swollen lymph nodes can be huge, much larger than those people get with a cold, and despite their size, many dogs with lymphoma seem to feel just fine.

With full chemotherapy, median survival times for dogs with lymphoma are about a year, with about 25 percent of dogs surviving more than two years.

Dogs with lymphoma who don't receive treatment typically pass away within a month.

Symptoms

Symptoms of lymphoma in dogs can be quite varied, but some common signs to look out for include swollen lymph nodes, which can feel like firm lumps under the skin.

Decreased appetite and lethargy are also common symptoms, as well as fever, weight loss, and vomiting. Diarrhea, increased thirst, and increased urination are other possible signs.

In some cases, lymphoma can cause facial or limb swelling, labored breathing, or red, flaky, itchy patches on the skin that eventually become open sores.

If your dog is experiencing any of these symptoms, it's essential to get them checked out by a veterinarian as soon as possible.

Lymphoma Spelled on Wooden Scrabble Pieces
Credit: pexels.com, Lymphoma Spelled on Wooden Scrabble Pieces

Here are some common symptoms of lymphoma in dogs, organized by category:

In some cases, lymphoma can cause more severe symptoms, such as respiratory distress, seizures, renal failure, blindness, or fractures and chronic pain.

Diagnosis

A biopsy is usually the first step in diagnosing canine lymphoma, where a veterinarian extracts a sample of cancer cells for microscopic analysis. This sample is then sent to a veterinary pathologist for further examination.

The pathologist will examine the sample and look for abnormal cells that can indicate lymphoma. They may also use special stains and other tests to determine the type of cancerous cells present.

Veterinarians may also order bloodwork and lab tests, such as a urinalysis, to check if the organs are functioning properly. This helps them understand the animal's overall condition and identify potential health issues that might affect the cancer treatment and prognosis.

Staging tests can include x-rays of the abdomen and chest, abdominal sonograms, as well as bone marrow aspiration. These tests help veterinarians determine how far the lymphoma has progressed throughout the body.

Dog with Intravenous Line on His Leg
Credit: pexels.com, Dog with Intravenous Line on His Leg

The staging of lymphoma is complicated, but it generally follows a specific outline:

Stages III-V are more common, and veterinarians rarely diagnose dogs in stages I and II.

Treatment and Prognosis

Treatment for lymphoma in dogs is a multi-faceted approach, and the best course of action depends on the individual dog and its pet parent.

Chemotherapy is the most effective treatment for almost every type of lymphoma, with over 90 percent of dogs treated with proven chemotherapy protocols going into remission.

Some types of lymphoma respond better to chemotherapy than others, but it's often the most effective treatment option.

A combination of therapies may be recommended, depending on the location of any masses and the type of lymphoma present.

Radiation therapy, corticosteroid therapy, and surgical therapy may also be used in conjunction with chemotherapy.

Here are the common types of treatment:

  • Multi-agent chemotherapy (often referred to as CHOP)
  • Single-agent chemotherapy
  • Corticosteroid therapy
  • Radiation therapy
  • Surgical therapy

The prognosis for a dog with lymphoma depends on the type of lymphoma, the cancer stage at the time of treatment, and the selected treatment.

Credit: youtube.com, How Lymphoma Develops

Generally, the more places the lymphoma has spread, the poorer the prognosis.

However, pets with very advanced lymphoma can still be treated and experience remission.

Treatment can extend a dog's life, but it rarely cures the disease completely, and most lymphoma patients will have a relapse sooner or later.

With full chemotherapy, median survival times are about a year, with about 25 percent of dogs surviving more than two years.

With steroid therapy alone, dogs can expect about two to three months with a good quality of life if their cancer responds to the drug.

Types and Forms of Lymphoma

Lymphoma in dogs is a complex and multifaceted disease. There are over 30 known types of canine lymphomas, but the most common ones are classified by location.

The four most common types of lymphoma in dogs are: Multicentric, affecting the lymph nodes (80 to 85 percent of lymphomas)Alimentary, affecting the gastrointestinal tract (5 to 7 percent of lymphomas)Mediastinal, affecting the thymus and lymph nodes in the chestExtranodal, affecting a specific organ, such as the skin, eyes, kidneys, lungs, or central nervous system

Dogs with multicentric lymphoma may have a high-grade B cell lymphoma, which is fortunately the type that responds best to chemotherapy.

Dog Breeds Prone to Cancer

Credit: youtube.com, Understanding Your Pet's Diagnosis: Lymphoma

Golden Retrievers are the most commonly affected breed when it comes to lymphoma, followed by Boxers, Bullmastiffs, Basset Hounds, Saint Bernards, Scottish Terriers, Airedales, and English Bulldogs.

Lymphoma can develop in any breed at any age, but these breeds seem to be at a higher risk.

Purebred dogs are nearly twice as likely to get cancer as mixed breeds, according to a study that looked at the cancer claims of 1.61 million dogs.

This means that if you have a purebred dog, it's essential to be aware of the potential risks and take steps to prevent cancer, such as keeping your dog at a healthy weight and providing regular exercise and veterinary check-ups.

Even in cases where chemotherapy isn't possible, simple corticosteroids like prednisone can keep lymphoma in remission for a little while, but pet parents need to be aware of the potential downsides of this treatment.

What Are the Types of?

Lymphoma classification can seem complex, but it's broken down into manageable parts. The four most common types of lymphoma in dogs are classified by location.

Credit: youtube.com, Lymphoma Explained Clearly - Hodgkins & Non-Hodgkin's Pathophysiology

Dogs can develop lymphoma in different parts of their body, including the lymph nodes, gastrointestinal tract, thymus and lymph nodes in the chest, and specific organs such as the skin, eyes, kidneys, lungs, or central nervous system.

The four main types of lymphoma are:

  • Multicentric (80 to 85 percent of lymphomas), affecting the lymph nodes
  • Alimentary (5 to 7 percent of lymphomas), affecting the gastrointestinal tract
  • Mediastinal, affecting the thymus and lymph nodes in the chest
  • Extranodal, affecting a specific organ

Each type of lymphoma is further classified based on how widely the cancer has spread, which is determined through staging. The staging system ranges from I to V, with a substage based on whether the dog is feeling sick or not.

Forms of Cancer

There are over 30 known types of canine lymphomas, each with its own unique symptoms, aggressiveness, and survival rates. Lymphoma can be a complex and overwhelming diagnosis for dog owners, but understanding the basics can help.

The most common types of canine lymphoma include multicentric, alimentary, mediastinal, and extranodal lymphoma. These types are classified by the location of the lymphoma in the body.

Credit: youtube.com, What Is Lymphoma?

Multicentric lymphoma is the most common type, affecting up to 85% of all cases, and primarily affects the lymph nodes. Alimentary lymphoma affects the gastrointestinal tract, while mediastinal lymphoma affects the thymus and lymph nodes in the chest. Extranodal lymphoma affects a specific organ, such as the skin, eyes, kidneys, lungs, or central nervous system.

The four most common types of lymphoma in dogs are:

  • Multicentric (80 to 85 percent of lymphomas), affecting the lymph nodes
  • Alimentary (5 to 7 percent of lymphomas), affecting the gastrointestinal tract
  • Mediastinal, affecting the thymus and lymph nodes in the chest
  • Extranodal, affecting a specific organ, such as the skin, eyes, kidneys, lungs, or central nervous system

Lymphoma can also be classified by the type of lymphocytes involved, such as B cells or T cells, and by the grade of the cancer, which can be high-grade or low-grade.

Primary Mediastinal

Primary Mediastinal lymphoma is a type of lymphoma that affects the mediastinum, which is the area in the chest that contains the heart, trachea, esophagus, and other vital organs.

Approximately 22 to 36% of all canine lymphoma cases have some degree of mediastinal involvement. This means that a significant portion of dogs with lymphoma will have mediastinal lymphoma.

Credit: youtube.com, Mediastinal Large B-Cell Lymphoma

Primary mediastinal lymphoma is most commonly a variant of high-grade, T-cell lymphoma. The study found that 28 cases were classified as T-cell phenotype and 1 case was B-cell phenotype.

Pleural effusion, which is the accumulation of fluid in the pleural space, was the only examined factor that correlated with decreased median overall survival. Dogs with pleural effusion had a median overall survival of 70 days.

The use of multi-agent CHOP chemotherapy significantly increased overall survival in canine patients. This is a promising finding, as it suggests that chemotherapy can be an effective treatment option for primary mediastinal lymphoma.

The mean age of dogs with primary mediastinal lymphoma was 7.8 years, and the mean weight was 33 kg. This suggests that primary mediastinal lymphoma can affect dogs of various ages and sizes.

Common blood chemistry abnormalities in dogs with primary mediastinal lymphoma include hypercalcemia, which was present in 68% of cases. Hypercalcemia was most prevalent in dogs with lymphoblastic lymphoma.

Nutrition and Health

Credit: youtube.com, Lymphoma 6 year survivor

A dog's diet plays a crucial role in their overall health, and it's especially important when they're dealing with lymphoma.

A well-balanced diet can help support a dog's immune system, which is essential for fighting off cancer cells.

A dog's nutritional needs change as they age, and it's recommended to feed them a senior dog food after they turn 7 years old.

Feeding a dog a high-quality protein source, such as chicken or salmon, can help support their overall health.

Some studies suggest that a diet rich in antioxidants, such as vitamins C and E, may help reduce the risk of cancer in dogs.

A dog's digestive health is also closely linked to their overall health, and a diet rich in fiber can help support their digestive system.

Some dog owners have reported that adding supplements, such as omega-3 fatty acids, to their dog's diet has helped improve their overall health.

Frequently Asked Questions

Does lymphoma come on suddenly in dogs?

Lymphoma in dogs can progress rapidly in some cases, appearing suddenly and aggressively, while in others it develops slowly over time. The speed of progression varies greatly depending on the type of lymphoma.

How do you know when to put a dog down with lymphoma?

When to put a dog down with lymphoma is often determined by the presence of severe symptoms such as labored breathing, incontinence, and loss of appetite, which can indicate a poor quality of life

What eventually kills a dog with lymphoma?

Eventually, a dog with lymphoma will die from organ failure, often in the bone marrow or liver, due to widespread cancer infiltration. This can lead to loss of appetite, vomiting, diarrhea, and severe weakness.

Shawna Welch

Writer

Shawna Welch is a versatile and engaging writer with a passion for exploring complex topics in an approachable way. With a keen interest in animal behavior, Shawna has developed a niche expertise in canine behavioral issues, shedding light on common problems and offering actionable advice for pet owners. Her writing style is characterized by clarity, empathy, and a commitment to accuracy, making her a trusted voice in the field.